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Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells. PLoS One 15(11):e0241440 (2020).
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Raman image-activated cell sorting. Nat Commun 11(1):3452 (2020).
Seo W, Shimizu K, Kojo S, Okeke A, Kohwi-Shigematsu T, Fujii SI, Taniuchi I.
Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity. Nat Commun 11(1):1562 (2020).
Isozaki A, Nakagawa Y, Loo MH, Shibata Y, Tanaka N, Setyaningrum DL, Park JW, Shirasaki Y, Mikami H, Huang D, Tsoi H, Riche CT, Ota T, Miwa H, Kanda Y, Ito T, Yamada K, Iwata O, Suzuki K, Ohnuki S, Ohya Y, Kato Y, Hasunuma T, Matsusaka S, Yamagishi M, Yazawa M, Uemura S, Nagasawa K, Watarai H, Di Carlo D, Goda K.
Sequentially addressable dielectrophoretic array for high-throughput sorting of large-volume biological compartments. Sci Adv 6(22):eaba6712 (2020).
Omori-Miyake M, Watarai H, Sato K, Ziegler SF, Yagi J.
An accumulation of two populations of dendritic cells in skin-draining lymph nodes in response to the expression of thymic stromal lymphopoietin in the skin. Cell Immunol 353:104116 (2020).
Mikami H, Kawaguchi M, Huang CJ, Matsumura H, Sugimura T, Huang K, Lei C, Ueno S, Miura T, Ito T, Nagasawa K, Maeno T, Watarai H, Yamagishi M, Uemura S, Ohnuki S, Ohya Y, Kurokawa H, Matsusaka S, Sun CW, Ozeki Y, Goda K.
Virtual-freezing fluorescence imaging flow cytometry. Nat Commun 11(1):1162 (2020).
Kanamori T, Numata T, Kuwabara S, Ishii Y, Watarai H, Yuasa H.
Photo effect on the CD1d-binding ability of azobenzene-attached analogues of α-GalCer. Bio Med Chem Lett 30(5):126960 (2020).
Kojo S, Ohno-Oishi M, Wada H, Nieke S, Seo W, Muroi S, Taniuchi I.
Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells. Life Sci Alliance 3(2):e202000642 (2020).
Nishida K, Hasegawa A, Yamasaki S, Uchida R, Ohashi W, Kurashima Y, Kunisawa J, Kimura S, Iwanaga T, Watarai H, Hase K, Ogura H, Nakayama M, Kashiwakura JI, Okayama Y, Kubo M, Ohara O, Kiyono H, Koseki H, Murakami M, Hirano T.
Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis. Sci Rep 9(1):10842 (2019).
Dashtsoodol N, Bortoluzzi S, Schmidt-Supprian M.
T cell receptor expression timing and signal strength in the functional differentiation of invariant natural killer T cells. Front Immunol 10:841 (2019).
Miyamoto C, Kojo S, Yamashita M, Moro K, Lacaud G, Shiroguchi K, Taniuchi I, Ebihara T.
Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation. Nat Commun 10(1):447 (2019).
Ren Y, Sekine-Kondo E, Tateyama M, Kasetthat T, Wongratanacheewin S, Watarai H.
New genetically manipulated mice provide insights into the development and physiological functions of invariant natural killer T cells. Front Immunol 9:1294 (2018).
Shimamoto Y, Nio-Kobayashi J, Watarai H, Nagano M, Saito N, Takahashi E, Higuchi H, Kobayashi A, Kimura T, Kitamura H.
Generation and validation of novel anti-bovine CD163 monoclonal antibodies ABM-1A9 and ABM-2D6. Vet Immunol Immunopathol 198(4):6-13 (2018).
Hiratsuka S, Tomita T, Matsunaga Y, Omori T, Mishima T, Ishibashi S, Watarai H, Yamamoto T, Shibata N, Watanabe A, Kijima H, Aburatani H, Tomura M, High KA, Maru Y.
Liver-primed immune cells regulate pre- and post- metastatic niche in the lung. EMBO Mol Med 10(7) pii: e8643 (2018).
Kojo S, Yasmin N, Muroi S, Tenno M, Taniuchi I.
Runx-dependent and silencer-independent repression of a maturation enhancer in Cd4 gene. Nat Commun 9(1):3593 (2018)
Shimamoto Y, Nio-Kobayashi J, Watarai H, Nagano M, Saito N, Takahashi E, Higuchi H, Kobayashi A, Kimura T, Kitamura H.
Generation and validation of novel anti-bovine CD163 monoclonal antibodies ABM-1A9 and ABM-2D6. Vet Immunol Immunopathol 198(4):6-13 (2018).
Mikami H, Harmon J, Kobayashi H, Hamad S, Wang Y, Iwata O, Suzuki K, Ito T, Aisaka Y, Kutsuna N, Nagasawa K, Watarai H, Ozeki Y, Goda K.
Ultrafast confocal fluorescence microscopy beyond the fluorescence lifetime limit. Optica 5(2):117-126 (2018).
Tenno M, Kojo S, Lawir DF, Hess I, Shiroguchi K, Ebihara T, Endo TA, Muroi S, Satoh R, Kawamoto H, Boehm T, Taniuchi I.
Cbfb2 controls differentiation of and confers homing capacity to prethymic progenitors. J Exp Med 215(2):595-610 (2018).
Dashtsoodol N, Shigeura T, Tashiro T, Aihara M, Chikanishi T, Okada H, Harada K, Sano H, Kurogi A, Taniguchi M.
Natural killer T cell-targeted immunotherapy mediatin long-term memory responses and strong antitumor activity. Front Immunol 8:1206 (2017).
Dashtsoodol N, Shigeura T, Aihara M, Ozawa R, Kojo S, Harada M, Endo TA, Watanabe T, Ohara O, Taniguchi M.
Altanative pathway for the development of Vα14+ NKT cells directly from CD4- CD8- thymocytes that bypasses the CD4+ CD8+ stage. Nat Immunol 18(3):274-282 (2017).
Ren Y, Sekine-Kondo E, Shibata R, Kato-Itoh M, Umino A, Yanagida A, Satoh M, Inoue K, Yamaguchi T, Mochida K, Nakae S, Van Kaer L, Iwabuchi K, Nakauchi H, Watarai H.
A novel mouse model of iNKT cell-deficiency generated by CRISPR/Cas9 reveals a pathogenic role of iNKT cells in metabolic disease. Sci Rep 7(1):12765 (2017).
Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I.
Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes. Nat Commun 8(1):702 (2017).
Hayatsu N, Miyao T, Tachibana M, Murakami R, Kimura A, Kato T, Kawakami E, Endo TA, Setoguchi R, Watarai H, Nishikawa T, Yasuda T, Yoshida H, Hori S.
Analyses of a mutant Foxp3 allele reveal BATF as a critical transcription factor in the differentiation and accumulation of tissue regulatory T cells. Immunity 47(2):268-283 (2017).
Jinnohara T, Kanaya T, Hase K, Sakakibara S, Tachibana N, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H.
IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med 214(6):1607-1618 (2017).
Eiamboonsert S, Salama Y, Watarai H, Dhahri D, Tsuda T, Okada Y, Hattori K, Heissig B.
The role of plasmin in the pathogenesis of murine multiple myeloma. Biochem Biophys Res Commun 488(2):387-392 (2017).
Kakugawa K, Kojo S, Tanaka H, Seo W, Endo TA, Kitagawa Y, Muroi S, Tenno M, Yasmin N, Kohwi Y, Sakaguchi S, Kowhi-Shigematsu T, Taniuchi I.
Essential roles of SATB1 in specifying T lymphocyte subsets. Cell Rep 19(6):1176-1188 (2017).
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Elucidation and control of the mechanisms underlying chronic inflammation mediated by invariant natural killer T cells. Chronic Inflammation, Springer,pp345-356 (2016).
Taya Y, Ota Y, Wilkinson AC, Kanazawa A, Watarai H, Kasai M, Nakauchi H, Yamazaki S.
Depleting dietary valine permits mouse hematopoietic stem cell transplantation. Science 354(6316):1152-1155 (2016).
Ohashi W, Kimura S, Iwanaga T, Furusawa Y, Irié T, Izumi H, Watanabe T, Hijikata A, Hara T, Ohara O, Koseki H, Sato T, Robine S, Mori H, Hattori Y, Watarai H, Mishima K, Ohno H, Hase K, Fukada T.
Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress. PLoS Genet 12(10):e1006349 (2016).
Satoh M, Namba K, Kitaichi N, Endo N, Kitamei H, Iwata D, Ohno S, Ishida S, Onoé K, Watarai H, Taniguchi M, Ishibashi T, Stein-Streilein J, Sonoda K, Van Kaer L, Iwabuchi K.
Protective role of invariant natural killer T cells in the development of experimental autoimmune uveoretinitis. Exp Eye Res 153:79-89 (2016).
Kanda M, Yamanaka H, Kojo S, Usui Y, Honda H, Sotomaru Y, Harada M, Taniguchi M, Suzuki N, Atsumi T, Wada H, Baghdadi M, Seino K.
Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-g production in iNKT cells. Proc Natl Acad Sci USA 113(24):E3394-3402 (2016).
Wakisaka Y, Suzuki Y, Iwata O, Nakashima A, Ito T, Hirose M, Domon R, Sugawara M, Tsumura N, Watarai H, Shimobaba T, Suzuki K, Goda K, Ozeki Y.
Probing the metabolic heterogeneity of live Euglena graciliswith label-free microscopy. Nat Microbiol 1(8):16124 (2016).
Dashtsoodol N, Shigeura T, Ozawa R, Harada M, Kojo S, Watanabe T, Koseki H, Nakayama M, Ohara O, Taniguchi M.
Generation of novel Traj18-deficient mice lacking Vα14 natural killer T cells with an undestrubed T cell receptor α-chain repertoire. PLoS One 11(4):e0153347 (2016).
Ushida M, Iyoda T, Kanamori M, Watarai H, Takahara K, Inaba K.
In vivo and in vitro analyses of α-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative. Immunol Lett 168(2):300-305 (2015).
Taniguchi M, Harada M, Dashtsoodol N, Kojo S.
Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy. Proc Jpn Acad Ser B Phys Biol Sci91(7):292-304 (2015).
Reynolds JM, Lee Y-H, Shi Y, Angkasekwinai P, Nallaparaju KC, Chang SH, Watarai H, Dong C.
Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation. Immunity 42(4):692-703 (2015).
Shimizu K, Sato Y, Shinga J, Watanabe T, Endo TA, Asakura M, Kawahara K, Kinjo Y, Kitamura H, Tsuji M, Watarai H, Ishii Y, Taniguchi M, Ohara O, Fujii SI.
KLRG+ invariant natural killer T cells are long-lived effectors. Proc Natl Acad Sci USA 111(34):12474-12479 (2014).
Ren Y, Dashtsoodol N, Watarai H, Koseki H, Quan C, Taniguchi M.
Generation of induced pluripotent stem cell-derived mice by reprogramming of a mature natural killer T cell. Int Immunol 26(10):551-561 (2014).
Shimizuhira C, Otsuka A, Honda T, Kitoh A, Egawa G, Nakajima S, Nakashima C, Watarai H, Miyachi Y, Kabashima K.
Natural killer T cells are essential for the development of contact hypersensitivity. J Invest Dermatol 134(11):2709-2718 (2014).
Shiozaki M, Tashiro T, Koshino H, Shigeura T, Watarai H, Taniguchi M, Mori K.
Synthesis of RCAI-172 (C6 epimer of RCAI-147) and its biological activity. Bioorg Med Chem 22(2):827-833 (2014).
Tarumoto N, Kinjo Y, Kitano N, Sasai D, Ueno K, Okawara A, Izawa Y, Shinozaki M, Watarai H, Taniguchi M, Takeyama H, Maesaki S, Shibuya K, Miyazaki S.
Exacerbation of invasive Candida albicans infection by commensal bacteria or a glycolipid through IFNγ produced in part by iNKT cells. J Infect Dis 209(5):799-810 (2014).
Shiozaki M, Tashiro T, Koshino H, Shigeura T, Watarai H, Taniguchi M, Mori K.
Synthesis and biological activity of hydroxylated analogues of RCAI-80. Tetrahedron 69(46):9710-9715 (2013).
Kudo H, Wada H, Sasaki H, Tsuji M, Otsuka R, Baghdadi M, Kojo S, Chikaraishi T, Seino K.
Induction of macrophage-like immunosupressive cells from mouse ES cells that contribute to prolong allogeneic graft survival. PLoS One 9(10):e111826 (2014)
Kitamura H, Kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, Naoe Y, Kikuguchi C, Meek B, Toda C, Okamoto S, Kanehira K, Hase K, Watarai H, Ishizuka M, El-Osta A, Ohara O, Miyoshi I.
Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. FASEB J 27(12):4940-4953 (2013).
Mera T, Itoh T, Kita S, Kodama S, Kojima D, Nishinakamura H, Okamoto K, Ohkura M, Nakai J, Iyoda T, Iwamoto T, Matsuda T, Baba A, Omori K, Ono J, Watarai H, Taniguchi M, Yasunami Y.
Pretreatment of donor islets with the Na+/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation. Am J Transplant 13(8):2154-2160 (2013).
Tashiro T, Shigeura T, Shiozaki M, Watarai H, Taniguchi M, Mori K.
RCAI-133, an N-methylated analogue of KRN7000, activates mouse natural killer T cells to produce Th2-biased cytokines. Med Chem Comm 4(6):949-955 (2013).
Tashiro T, Nakagawa R, Shigeura T, Watarai H, Taniguchi M, Mori K.
RCAI-61 and related 6'-modified analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce interferon-γ in vivo. Bioorg Med Chem 21(11):3066-3079 (2013).
Shiozaki M, Tashiro T, Koshino H, Shigeura T, Watarai H, Taniguchi M, Mori K.
Synthesis and biological activity of hydroxylated analogues of KRN7000 (α-galactosylceramide). Carbohydr Res 370:46-66 (2013).
Wada H, Kojo S, Seino K.
Mouse models of human INAD by Pla2g6 deficiency. Histol Histopathol 28(8):965-969 (2013)
Tarumoto N, Kinjo Y, Ueno K, Okawara A, Watarai H, Taniguchi M, Maesaki S, Miyazaki Y. A limited role for iNKT cells in controlling systemicCandida albicansinfection. Jpn J Infect Dis 65(6):522-528 (2012).
Watarai H, Taniguchi M.
Induction of allergic responses mediated by invariant NKT. Arerugi 61(6):798-804 (2012).
Tashiro T, Shigeura T, Watarai H, Taniguchi M, Mori K.
RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines. Bioorg Med Chem 20(14):4540-4548 (2012).
Watarai H, Yamada D, Fujii SI, Taniguchi M, Koseki H.
Induced pluripotency as a potential path towards iNKT cell-mediated cancer immunotherapy. Int J Haematol 95(6):624-631 (2012).
Watarai H, Sekine-Kondo E, Motomura H, Yasuda T, Yoshida H, Kubo M, Koseki H, Taniguchi M.
Development and function of invariant natural killer T cells producing TH2- and TH17-cytokines. PLoS Biol 10(2):e1001255 (2012).
Watarai H, Harada M, Tamari M, Taniguchi M.
A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders. Inflammation and Allergy Drug Design, Wiley Blackwell, pp59-66 (2011).
Hosonuma S, Kobayashi Y, Kojo S, Wada H, Seino K, Ishizuka B.
Clinical significance of side population in ovarian cancer cells. Hum Cell 24(1):9-12 (2011)
Kobayashi Y, Seino K, Hosonuma S, Ohara T, Itamochi H, Isonishi S, Kita T, Wada H, Kojo S, Kiguchi K.
Side population is increased in paclitaxel-resistant ovarian cancer cell lines regardless of resistance to cisplatin. Gynecol Oncol 121(2):390-394 (2011)
Taniguchi M, Fujii S, Nakayama T, Motohashi S, Dashtsoodol N, Watarai H.
Mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells. Natural Killer T cells: Balancing the Regulation of Tumor Immunity, Springer,pp1-14 (2011).
Tashiro T, Ishii Y, Shigeura T, Nakagawa R, Watarai H, Taniguchi M, Mori K.
RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles. Med Chem Commun 2(7):620-625 (2011).
Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K.
Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells. Int Immunol 23(1):65-74 (2011)
Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M.
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12(5):450-459 (2011).